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San Francisco 49ers vs Arizona Cardinals NFL Odds and Prediction

The NFL’s top rusher, Carlos Hyde (211 yards, 2 TDs), will be on display when the San Francisco 49ers (1-1) meet the Arizona Cardinals (2-0). The Cardinals are 2-0 and the 49ers have a 1-1 record this season. The game will begin Sunday, Sep 27 at 4:05 p.m. ET and can be seen on FOX.

This will be the first matchup of the season for the division rivals. They split a pair of games during the regular season last year. Glenn Carson led the Cardinals defense in the last game, totaling six tackles. Aaron Lynch led the way for the San Francisco defense, registering two tackles and one sack.

The Cardinals, a six-point favorite, will be looking to keep home-field advantage when San Francisco visits. The Over/Under (O/U) for the matchup is 44 points.

Heading into Week 3 of league action, the Cardinals are unbeaten with a 2-0 record Straight Up (SU) and Against The Spread (ATS). They come into the game with the top ranked scoring offense in the league, averaging 39.5 points per game. Look for Arizona to take advantage of an inferior San Francisco pass defense, which ranks 26th in the league with 273 yards per game. The Cardinals defense has performed extremely well this season, giving up a league-best 21.0 points per game. Arizona’s offense gets production early, averaging a league-best 10.5 points in the first quarter.

Compared to the Cardinals, the 49ers have a record of 1-1 both ATS and SU. The 49ers depend heavily on their run game, averaging 35 rushing attempts per game. San Francisco uses an uptempo offense. The team has an average time of possession of 35:00 this season, ranking third in the league.

Predictions: SU Winner – Ari, ATS Winner – Ari, O/U – Under

Notes

The total has gone OVER in 4 of Arizona’s last 5 games.

Arizona is 16-7 SU in its last 23 games.

Arizona is 8-1 SU in its last 9 games at home.

Arizona is 1-5 SU in its last 6 games when playing San Francisco.

Arizona is 4-9 ATS in its last 13 games when playing San Francisco.

Arizona is 2-7 ATS in its last 9 games when playing at home against San Francisco.

The total has gone UNDER in 4 of Arizona’s last 6 games when playing at home against San Francisco.

Arizona is 2-4 SU in its last 6 games when playing at home against San Francisco.

San Francisco is 1-0 SU when leading at the half this season. Arizona is 2-0 SU when taking a lead into halftime.

Dating back to last season, Arizona is an even 3-3 SU against NFC West opponents, while San Francisco is just 2-4 SU against division foes.

San Francisco is rated higher in the ground game on both sides of the ball. Its second-ranked rushing attack will face the 10th-ranked run defense of Arizona, while its sixth-ranked run defense will look to contain the 13th-ranked rushing game of the Cardinals.

Written by GMS Previews

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